Frydrych Ivo Ph.D.

Journals

KAZAKOVA, A., I. FRYDRYCH, N. JAKUBCOVÁ, J. POKORNÝ, B. LIŠKOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells - Synthesis, potency, and mitochondrial mechanism of action. European Journal of Medicinal Chemistry. 2024, 269, 116336, ISSN: 0223-5234, PMID: 38520761,  PDF.
LIGASOVÁ, A., I. FRYDRYCH, K. KOBERNA
Basic Methods of Cell Cycle Analysis. International Journal of Molecular Sciences. 2023, 24(12), 3674, ISSN: 1422-0067, PMID: 36835083,  PDF.
BORKOVÁ, L., I. FRYDRYCH, B. VRÁNOVÁ, N. JAKUBCOVÁ, B. LIŠKOVÁ, P. DŽUBÁK, P. PAVLIŠ, M. HAJDÚCH, M. URBAN
Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes. European Journal of Medicinal Chemistry. 2022, 244, 114850, ISSN: 0223-5234, PMID: 36283179,

Books & book chapters

FRYDRYCH, I.
Reporters based on luminescence or fluorescence detection , 1.vyd., Olomouc, Palacky University, 2021, 20, 147-152, Dedication: LO1304, ISBN: 978-80-244-6049-9,
FRYDRYCH, I.
Cell cycle analysis by flow cytometry , 1.vyd., Olomouc, Palacky University, 2021, 26, 193-200, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Intellectual property

SONIC HEDGEHOG (Urban)
  1. Patent: CZ 309885. Granted: 30.11.2023. Ownership: Palacký University Olomouc. Inventors: URBAN Milan, FRYDRYCH Ivo, BORKOVÁ Lucie, VRÁNOVÁ Barbora, HAJDÚCH Marián. 

Status: Available

METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMENS FOR OVERCOMING RESISTANCE (Khushboo)
  1. Patent: EP 2924125 (ASH1L). Granted: 17.6.2017. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián
  2. Patent: EP 3042650 (JQ1). Granted: 10.6.2020. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián
  3. Published Application PCT/CZ2015/000029 under WO 2015/144102 (1.10.2015)
  4. Patent: EP 3122902 (BRD4). Granted: 16.5.2018. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián
  5. Published Application US 15/128,390 under US 20180251847 (6.9.2018)
  6. Patent: JP 6463372 (BRD4). Granted: 11.1.2019. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián

​Status: Available 

Master mentorship

Reiterová Ivana

Preparation of cell-based reporter assay for high-throughput screening of small molecules as potential receptor for advanced glycation endproducts inhibitors

Status: Graduated from 2015 to 2017.

Bachelor mentorship

Kollárová Ema

Study of biological activity of new betulin derivatives

Status: Ongoing from 2023.
Pitnerová Monika

Targeting Hedgehog signaling by betulinic acid derivatives

Status: Ongoing from 2021.