IMTM

Education:

1989-1993                  Secondary Grammar School Strážnice,

                                   specialization: Natural Sciences

1993-1998                  Master´s degree in Biology and Chemistry

 Faculty of Natural Sciences, Palacký University in Olomouc 

1.10.1998-23.1.2003  PhD degree study programme in Laboratory of Experimental

                                   Medicine, Department of Paediatrics, Palacký

                                   University and Faculty Hospital in Olomouc

Experiences:

2.2.-30.7.2001  Exchange study programme  (1semester), University of Wolverhampton, England

22.5.2005  Attestation exam in „Investigative methods in  medical genetic – clinical cytogenetic“

                                  17.3.2006  Certificate of auditor for laboratries , The Czech Society for Quality

21.11.2007  Certificate of Quality Manager of  Laboratory, The Czech Society for Quality

                                  25.2.2004-2008  Member of Paediatric Board in Palacky Universizy

           22.6.2004- 15.3.2007 Special consultant of Medical faculty, Palacky University for genetically modified organsims

 Employed:  

1.1.2002- Laboratory of Experimental Medicine (part of IMTM from 2010),  Department of Cytogenetic, Paediatric Clinic, 

                Palacký University and Faculty Hospital in Olomouc

Major interests:       

Cytogenetic changes in patients with solid tumours

Member of:

16.6.2003   Czech Oncological Society (Czech Medical Association of J. E. Purkinje Olomouc)

17.8.2004   European Cytogeneticists Association (E.C.A.)

8.2.2007    Member of Czech Society For Quality

Publications (Impact Factor Journals):

• [19]
  ŠPORIKOVÁ , Z., V. KOUDELÁKOVÁ, R. TROJANEC a M. HAJDÚCH. Genetic Markers in Triple-Negative Breast Cancer. Clinical Breast Cancer. 2018, 18(5), e841-e850. ISSN 1526-8209. IF: 2.703. PMID: 30146351
• [18]
  KOLEČKOVÁ, M., Z. KOLÁŘ, J. EHRMANN, G. KOŘÍNKOVÁ a R. TROJANEC. Age-associated prognostic and predictive biomarkers in patients with breast cancer. Oncology Letters. 2017, 13(6), 4201-4207. ISSN 1792-1074. IF: 1.482. PMID: 28599421
• [17]
  KALITA, O., R. TROJANEC, M. HOUDOVÁ MEGOVÁ , M. HAJDÚCH, M. VAVERKA, L. HRABALEK, M. ZLEVOROVA, J. DRÁBEK, L. TUČKOVÁ a J. VRBKOVÁ. Glioblastoma multiforme in patients with history of extracranial cancer: Case series. Clinical Neurology and Neurosurgery. 2016, 144(-), 39-43. ISSN 0303-8467. IF: 1.381. PMID: 26971293
• [16]
  KOUDELÁKOVÁ, V., R. TROJANEC, J. VRBKOVÁ, S. DONEVSKA, K. BOUCHALOVÁ, M. KOLÁŘ, L. VARANASI a M. HAJDÚCH. Frequency of chromosome 17 polysomy in relation to CEP17 copy number in a large breast cancer cohort. Genes Chromosomes & Cancer. 2016, 55(5), 409-17. ISSN 1045-2257 . IF: 3.696. PMID: 26847577
• [15]
  KOUDELÁKOVÁ, V., J. BERKOVCOVÁ, R. TROJANEC, J. VRBKOVÁ, L. RADOVÁ, J. EHRMANN, Z. KOLÁŘ, B. MELICHAR a M. HAJDÚCH. Evaluation of HER2 Gene Status in Breast Cancer Samples with Indeterminate Fluorescence in Situ Hybridization by Quantitative Real-Time PCR Method. Journal of Molecular Diagnostic. 2015, 17(4), 446-455. ISSN 1525-1578. IF: 5.201. PMID: 25956448
• [14]
  BOUCHALOVÁ, K., M. SVOBODA, G. KHARAISHVILI, J. VRBKOVÁ, J. BOUCHAL, R. TROJANEC, V. KOUDELÁKOVÁ, L. RADOVÁ, K. CWIERTKA, M. HAJDÚCH a Z. KOLÁŘ. BCL2 is an independent predictor of outcome in basal-like triple-negative breast cancers treated with adjuvant anthracycline-based chemotherapy. Tumor Biology. 2015, 36(6), 4243-52. ISSN 1010-4283 . IF: 2.926. PMID: 25616695
• [13]
  GACHECHILADZE, M., J. ŠKARDA, M. IBRAHIM, T. TICHÝ, P. FLODR, P. LÁTALOVÁ, J. EHRMANN, R. TROJANEC a Z. KOLÁŘ. Primitive neuroectodermal tumor (PNET) of the lung in an adult woman. World Journal of Surgical Oncology. 2014, 12(-), -. ISSN 1477-7819. IF: 1.408. PMID: 25475214
• [12]
  HOUDOVÁ MEGOVÁ , M., J. DRÁBEK, V. KOUDELÁKOVÁ, R. TROJANEC, O. KALITA a M. HAJDÚCH. Isocitrate dehydrogenase 1 and 2 mutations in gliomas. Journal of Neuroscience Research. 2014, 92(12), 1611-1620. ISSN 0360-4012. IF: 2.594. PMID: 25078896
• [11]
  BALIK, V., R. TROJANEC, M. HOLZEROVA, L. TUČKOVÁ, I. SULLA, M. HOUDOVÁ MEGOVÁ , M. VAVERKA, L. HRABALEK a J. EHRMANN. An adult multifocal medulloblastoma with diffuse acute postoperative cerebellar swelling: immunohistochemical and molecular genetics analysis. Neurosurgical Review. 2015, 38(1), 1-10. ISSN 0344-5607. IF: 2.166. PMID: 24913771
• [10]
  KOUDELÁKOVÁ, V., M. MEGOVÁ, R. TROJANEC, J. DRÁBEK a M. HAJDÚCH. Non-small cell lung cancer - genetic predictors. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2013, 157(2), 125-136. ISSN 1213-8118. IF: 1.661. PMID: 23733083
• [9]
  ČÍŽKOVÁ, M., K. BOUCHALOVÁ, D. FRIEDECKÝ, A. POLYNKOVA, A. JANOŠŤÁKOVÁ, L. RADOVÁ, K. CWIERTKA, R. TROJANEC, M. ZEZULOVÁ, M. ZLEVOROVA, M. HAJDÚCH a B. MELICHAR. High lapatinib plasma levels in breast cancer patients: risk or benefit?. Tumori. 2012, 98(1), 162-165. ISSN 0300-8916. IF: 0.922. PMID: 22495718
• [8]
  BOUCHALOVÁ, K., M. ČÍŽKOVÁ, K. CWIERTKA, R. TROJANEC, D. FRIEDECKÝ a M. HAJDÚCH. Lapatinib in breast cancer - the predictive significance of HER1 (EGFR), HER2, PTEN and PIK3CA genes and lapatinib plasma level assessment. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2010, 154(4), 281-288. ISSN 1213-8118. IF: 0.716. PMID: 21293538
• [7]
  KREJCI, K., T. TICHÝ, P. HORAK, H. CIFERSKA, M. HAJDÚCH, J. SROVNAL, R. TROJANEC, M. ZEZULOVÁ, M. ZLEVOROVA, L. KALINOVA a J. ZADRAZIL. Merkel Cell Carcinoma of the Gluteal region with Ipsilateral Metastasi into the Pancreatic Graft of Patient after Combined Kidney-Pancreas Transplantation. Onkologie. 2010, 33(-), 520-524. ISSN 0378-584X. IF: 1.156. PMID: 20926899
• [6]
  SOUCEK, K., P. GAJDUSKOVA, M. BRAZDOVA, M. HYZDALOVA, L. KOCI, D. VYDRA, R. TROJANEC, Z. PERNICOVA, L. LENTVORSKA, M. HAJDÚCH, J. HOFMANOVA a A. KOZUBIK. Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation. Cancer Genetics and Cytogenetics. 2010, 197(2), 107-116. ISSN 0165-4608. IF: 1.551. PMID: 20193843
• [5]
  HRABALEK, L., O. KALITA, H. ŠVÉBIŠOVÁ, J. EHRMANN, M. HAJDÚCH, R. TROJANEC a M. KALA. Dumbbell-shaped peripheral primitive neuroectodermal tumor of the spine-case report and review of the literature. Journal of Neuro-Oncology. 2009, 92(2), 211-217. ISSN 0167-594X. IF: 2.323. PMID: 19050994
• [4]
  KALITA, O., M. KALA, H. ŠVÉBIŠOVÁ, J. EHRMANN, A. HLOBILKOVA, R. TROJANEC, M. HAJDÚCH a M. HOUDEK. Glioblastoma multiforme with an abscess: case report and literature review. Journal of Neuro-Oncology. 2008, 88(2), 221-225. ISSN 0167-594X. IF: 1.856. PMID: 18317688
• [3]
  ÜBERALL, I., Z. KOLÁŘ, R. TROJANEC, J. BERKOVCOVÁ a M. HAJDÚCH. The status and role of ErbB receptors in human cancer. Experimental and Molecular Pathology. 2008, 84(2), 79-89. ISSN 0014-4800. IF: 1.822. PMID: 18279851
• [2]
  BOUCHALOVÁ, K., R. TROJANEC, Z. KOLÁŘ, K. CWIERTKA, I. ČERNÁKOVÁ, V. MIHÁL a M. HAJDÚCH. Analysis of ERBB2 and TOP2A gene status using fluorescence in situ hybridization versus immunohistochemistry in localized breast cancer. Neoplasma. 2006, 53(5), 393-401. ISSN 0028-2685. IF: 0.731. PMID: 17013533
• [1]
  NOSKOVA, V., P. DŽUBÁK, G. KUZMINA, A. LUDKOVÁ, D. STEHLÍK, R. TROJANEC, A. JANOŠŤÁKOVÁ, G. KOŘÍNKOVÁ, V. MIHÁL a M. HAJDÚCH. In vitro chemoresistance profile and expression/function of MDR associated proteins in resistant cell lines derived from CCRF-CEM, K562, A549 and MDA MB 231 parental cells. Neoplasma. 2002, 49(6), 418-425. ISSN 0028-2685. IF: 0.637. PMID: 12584592

Publications (Other Reviewed Journals):

• [3]
  HOUDOVÁ MEGOVÁ , M., J. DRÁBEK, Z. DWIGHT, R. TROJANEC, V. KOUDELÁKOVÁ, J. VRBKOVÁ, O. KALITA, S. MLČOCHOVÁ, M. RABČANOVÁ a M. HAJDÚCH. Isocitrate Dehydrogenase Mutations are Better Prognostic Marker than O6-methylguanine-DNA Methyltransferase Promoter Methylation in Glioblastomas - a Retrospective, Single-centre Molecular Genetics Study of Gliomas. Klinická onkologie. 2017, 30(5), 361-371. ISSN 0862-495X.
• [2]
  KALITA, O., M. ZLEVOROVA, M. HOUDOVÁ MEGOVÁ , M. VAVERKA, R. TROJANEC a L. TUČKOVÁ. Pacientka s primárním intraventrikulárním gliosarkomem s dlouhodobým přežíváním - kazuistika. Klinická onkologie. 2016, 29(6), 454-459. ISSN 0862-495X.
• [1]
  HRABALEK, L., O. KALITA, H. ŠTUDENTOVÁ, J. JANKOVA, J. EHRMANN, R. TROJANEC a M. HAJDÚCH. Intramedullary spinal cord and cauda equina metastasis of breast carcinoma: case report. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2010, 154, 1-3. ISSN 1213-8118.

Book Chapters:

• [1]
  HAJDÚCH, M., J. DRÁBEK a R. TROJANEC. Význam biomarkerů pro indikaci cílené biologické léčby v onkologii. In: Biologická léčiva: Teoretické základy a klinická praxe. 1. vyd. Praha: Grada Publishing, 2012. Kapitola 2.8, s. 137-149. ISBN: 978-80-247-3727-0.

Books:

• [3]
  BOUCHALOVA, K., M. HAJDUCH, J. BOUCHAL, A. HLOBILKOVA, M. HOUDOVA MEGOVA , M. HUDCOVA, V. KOUDELAKOVA, J. MEDALOVA, J. SROVNAL a R. TROJANEC. Prediktivní a prognostická onkologie. 1. vyd. Olomouc: Univerzita Palackého v Olomouci, 2016. 122 s. ISBN: 978-80-244-3188-8.
• [2]
  DRABEK, J., J. BERKOVCOVA, P. DŽUBAK, M. HAJDUCH, M. KHOYLOU, V. KOUDELAKOVA, J. SROVNAL, M. STAŇKOVA a R. TROJANEC. Detekce nádorových biomarkerů v molekulárně biologické laboratoři. 1. vyd. Olomouc: Univerzita Palackého v Olomouci, 2012. 144 s. ISBN: 978-80-244-3002-7.
• [1]
  HAJDUCH, M., J. DRABEK a R. TROJANEC. Biologická léčiva: Teoretické základy a klinická praxe. 1. vyd. Praha: Grada Publishing, 2012. 219 s. ISBN: 978-80-247-3727-0.