Urban Milan Ph.D.

Journals

ORSÁG, Š., I. FRYDRYCH, B. LIŠKOVÁ, S. GURSKÁ, A. PRIBYLKA, J. HODOŇ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Synthesis and biological evaluation of novel C-30 modified lupane triterpenoids selectively cytotoxic against cancer cells. European Journal of Medicinal Chemistry. 2025, 302 (Pt 1), 118268, ISSN: 0223-5234 , PMID: 41124881,  PDF.
FRYDRYCH, I., J. ŘEHULKA, L. SLAVIKOVA, J. HODOŇ, J. HODOŇ, J. POKORNÝ, V. ŠIDOVÁ, M. MEDVEDÍKOVÁ, H. SLAVÍK, P. POLISHCHUK, T. OŽDIAN, J. VRBKOVÁ, J. ŠAREK, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Triterpenoid derivatives inhibit Gli-mediated transcription in human glioblastoma cell line via direct interaction with Gli1. The Journal of biological chemistry. 2025, ISSN: 0021-9258, PMID: 40651614,  PDF.
FRYDRYCH, I., B. CHROMA, L. SLAVIKOVA, J. POKORNÝ, N. JAKUBCOVÁ, S. LUDHA, S. GURSKÁ, J. ŘEHULKA, B. LIŠKOVÁ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Novel C-2 Aromatic Heterocycle-Substituted Triterpenoids Inhibit Hedgehog Signaling in GLI1 Overexpression Cancer Cells. ACS Omega. 2025, 10(10), 10617-10632, ISSN: 2470-1343, PMID: 40124057,  PDF.

Books & book chapters

DŽUBÁK, P., M. URBAN, M. HAJDÚCH
Vývoj nových léčiv, 1. vyd, Praha, Galén, 2015, 11, 469-472, ISBN: 978-80-7492-121-6,
URBAN, M., M. KVASNICA, N. DICKINSON, J. ŠAREK
Biologically Active Triterpenoids Usable As Prodrugs, 1. vyd, New York, USA, Nova Science Publishers, 2015, 2, 25-50, Dedication: CZ.1.05/2.1.00/01.0030, ISBN: 978-1-63463-656-8,
ŠAREK, J., M. KVASNICA, M. VLK, M. URBAN, P. DŽUBÁK, M. HAJDÚCH
The Potential of Triterpenoids in the Treatment of Melanoma, 1.vyd, Rijeka, InTech, 2011, 7, 125-158, Dedication: 305/09/1216, ISBN: 978-953-307-293-7,

Intellectual property

SONIC HEDGEHOG (Urban)
  1. Patent: CZ 309885. Granted: 30.11.2023. Ownership: Palacký University Olomouc. Inventors: URBAN Milan, FRYDRYCH Ivo, BORKOVÁ Lucie, VRÁNOVÁ Barbora, HAJDÚCH Marián. 

Status: Terminated

TERPENOID DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN NEUROPROTECTION (Urban)
  1. Patent: CZ 309944. Inventors: URBAN Milan, GONZALEZ Gabriel, HODOŇ Jiří, STRNAD Miroslav. Ownership: Palacký University Olomouc.
  2. Published Application: PCT/CZ2021/050146 under WO 2022/117133 (9.6.2022). Inventors: URBAN Milan, GONZALEZ Gabriel, HODOŇ Jiří, STRNAD Miroslav. Ownership: Palacký University Olomouc.

 Status: Available 

Doctoral mentorship

Bachořík Jan

Preparation of semisynthetic triterpenes

Stav: Probíhající od 2019.
Orság Šimon

Preparation of new heterocyclic derivatives of triterpene

Stav: Probíhající od 2022 do 2022.
Jurčeka Ondřej

Modification of lupine triterpenes in position C-17

Stav: Probíhající od 2022.

Master mentorship

Horka Vladimír

Conjugates of betulin prepared by cycloaddition reactions

Stav: Absolvoval od 2018 do 2020.
Pisár Martin

Preparation of semisynthetic derivatives of betulinic acid with cytotoxic activity

Stav: Absolvoval od 2017 do 2019.
Olejníková Denisa

Synthesis of new lupane derivatives modified at position 20 or 30

Stav: Absolvoval od 2018 do 2020.

Bachelor mentorship

Zamazal Viktor

Preparation of new triterpene derivatives based on sulfur

Stav: Absolvoval od 2022 do 2024.
Jarošová Amálie

Preparation of new nitrogen-based triterpene derivatives

Stav: Probíhající od 2022.
Oriešková Eliška

Preparation of new triterpene derivatives based on peptides

Stav: Absolvoval od 2022 do 2024.

Open positions

Projekt: Natural compounds with anti tumor activity
Vedoucí: Urban Milan Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: 2 full-time positions
Projekt: Research and development of agents for cancer, neurodegenerative and infectious diseases
Vedoucí: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
K dispozici: 5
Určeno pro: Doktorské studium