Urban Milan Ph.D.

Journals

FRYDRYCH, I., J. ŘEHULKA, L. SLAVIKOVA, J. HODOŇ, J. HODOŇ, J. POKORNÝ, V. ŠIDOVÁ, M. MEDVEDÍKOVÁ, H. SLAVÍK, P. POLISHCHUK, T. OŽDIAN, J. VRBKOVÁ, J. ŠAREK, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Triterpenoid derivatives inhibit Gli-mediated transcription in human glioblastoma cell line via direct interaction with Gli1. The Journal of biological chemistry. 2025, ISSN: 0021-9258, PMID: 40651614,  PDF.
FRYDRYCH, I., B. CHROMA, L. SLAVIKOVA, J. POKORNÝ, N. JAKUBCOVÁ, S. LUDHA, S. GURSKÁ, J. ŘEHULKA, B. LIŠKOVÁ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Novel C-2 Aromatic Heterocycle-Substituted Triterpenoids Inhibit Hedgehog Signaling in GLI1 Overexpression Cancer Cells. ACS Omega. 2025, 10(10), 10617-10632, ISSN: 2470-1343, PMID: 40124057,  PDF.
KAZAKOVA, A., I. FRYDRYCH, N. JAKUBCOVÁ, J. POKORNÝ, B. LIŠKOVÁ, S. GURSKÁ, R. BURIÁNOVÁ, A. PRIBYLKA, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Triterpenoid phthalimides as selective anti-cancer agents targeting mitochondrial apoptosis. European Journal of Medicinal Chemistry. 2024, ISSN: 0223-5234, PMID: 39673861,  PDF.

Books & book chapters

DŽUBÁK, P., M. URBAN, M. HAJDÚCH
Vývoj nových léčiv, 1. vyd, Praha, Galén, 2015, 11, 469-472, ISBN: 978-80-7492-121-6,
URBAN, M., M. KVASNICA, N. DICKINSON, J. ŠAREK
Biologically Active Triterpenoids Usable As Prodrugs, 1. vyd, New York, USA, Nova Science Publishers, 2015, 2, 25-50, Dedication: CZ.1.05/2.1.00/01.0030, ISBN: 978-1-63463-656-8,
ŠAREK, J., M. KVASNICA, M. VLK, M. URBAN, P. DŽUBÁK, M. HAJDÚCH
The Potential of Triterpenoids in the Treatment of Melanoma, 1.vyd, Rijeka, InTech, 2011, 7, 125-158, Dedication: 305/09/1216, ISBN: 978-953-307-293-7,

Intellectual property

SONIC HEDGEHOG (Urban)
  1. Patent: CZ 309885. Granted: 30.11.2023. Ownership: Palacký University Olomouc. Inventors: URBAN Milan, FRYDRYCH Ivo, BORKOVÁ Lucie, VRÁNOVÁ Barbora, HAJDÚCH Marián. 

Status: Terminated

TERPENOID DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN NEUROPROTECTION (Urban)
  1. Patent: CZ 309944. Inventors: URBAN Milan, GONZALEZ Gabriel, HODOŇ Jiří, STRNAD Miroslav. Ownership: Palacký University Olomouc.
  2. Published Application: PCT/CZ2021/050146 under WO 2022/117133 (9.6.2022). Inventors: URBAN Milan, GONZALEZ Gabriel, HODOŇ Jiří, STRNAD Miroslav. Ownership: Palacký University Olomouc.

 Status: Available 

Doctoral mentorship

Bachořík Jan

Preparation of semisynthetic triterpenes

Stav: Probíhající od 2019.
Orság Šimon

Preparation of new heterocyclic derivatives of triterpene

Stav: Probíhající od 2022 do 2022.
Jurčeka Ondřej

Modification of lupine triterpenes in position C-17

Stav: Probíhající od 2022.

Master mentorship

Maršálková Natálie

Stav: Probíhající.
Horka Vladimír

Conjugates of betulin prepared by cycloaddition reactions

Stav: Absolvoval od 2018 do 2020.
Pisár Martin

Preparation of semisynthetic derivatives of betulinic acid with cytotoxic activity

Stav: Absolvoval od 2017 do 2019.

Bachelor mentorship

Zamazal Viktor

Preparation of new triterpene derivatives based on sulfur

Stav: Probíhající od 2022.
Jarošová Amálie

Preparation of new nitrogen-based triterpene derivatives

Stav: Probíhající od 2022.
Oriešková Eliška

Preparation of new triterpene derivatives based on peptides

Stav: Probíhající od 2022.

Open positions

Projekt: Natural compounds with anti tumor activity
Vedoucí: Urban Milan Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: 2 full-time positions
Projekt: Research and development of agents for cancer, neurodegenerative and infectious diseases
Vedoucí: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
K dispozici: 5
Určeno pro: Doktorské studium