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Academic title: Prof. Dr.
Phone: +420 588444231, +420 585632152
Groups: IMTM, METABOLOMICS, STAFF

About me

Senior researcher, Professor, Biochemistry and Metabolomics

Main areas of research

Prof. Tomas Adam started working in diagnosing metabolic diseases as well as in development of diagnostic biochemical methods based on modern separation and mass spectrometry techniques. This led to subsequent development of metabolomic laboratory and relevant working pipelines.  He is involved in research of nucleotide metabolism in relation to inherited metabolic disorders, expanded newborn metabolic screening, developing novel statistical approaches to metabolic data and drug metabolism research in relation to cancer. In the last period he is focused on clinical applications and data analysis in metabolomics.

From a technological point of view is skilled in techniques such as liquid chromatography, capillary electrophoresis, mass spectrometry (QqQ, Orbitrap, ESI, high-throughput flow injection analysis, MS2/MS3 HR/AM fragmentation).

Last couple of years he has focused on metabolomics (targeted/untargeted approach - data processing, interpretation, analysis of bodyfluids, cells, tissues – clinical applications).

Journals

NAJDEKR, L., A. GARDLO, L. MÁDROVÁ, D. FRIEDECKÝ, H. JANEČKOVÁ, E. CORREA, R. GOODACRE, T. ADAM
Oxidized phosphatidylcholines suggest oxidative stress in patients with medium-chain acyl-CoA dehydrogenase deficiency. Talanta. 2015, 139(2015), 62-66, ISSN: 0039-9140, PMID: 25882409,
LIGASOVÁ, A., D. STRUNIN, D. FRIEDECKÝ, T. ADAM, K. KOBERNA
A fatal combination: a thymidylate synthase inhibitor with DNA damaging activity. PLOS One. 2015, 10(2), 1-21, ISSN: 1932-6203, PMID: 25671308,  PDF.
JANEČKOVÁ, H., A. KALIVODOVÁ, L. NAJDEKR, D. FRIEDECKÝ, K. HRON, P. BRUHEIM, T. ADAM
Untargeted metabolomic analysis of urine samples in the diagnosis of some inherited metabolic disorders. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2015, 159(4), 582-585, ISSN: 1213-8118, PMID: 25482736,

Open positions

1 Medical biology
Project: Cellular fluxomic analysis for the research of pathobiochemical processes
Supervisors: Adam Tomáš Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 place in full-time or combined form of study
2 Molecular and Translational Medicine
Project: Cellular fluxomic analysis for research of pathobiochemical processes
Supervisors: Adam Tomáš Ph.D.
Available: 1
Intended for: Doctoral training
Project: Diagnosis and treatment of rare diseases
Supervisors: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D., Adam Tomáš Ph.D.
Available: 3
Intended for: Doctoral training
Summary: 3 full-time positions