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Academic title: Prof. Dr.
Phone: +420 588444231, +420 585632152
Groups: IMTM, METABOLOMICS, STAFF

About me

Senior researcher, Professor, Biochemistry and Metabolomics

Main areas of research

Prof. Tomas Adam started working in diagnosing metabolic diseases as well as in development of diagnostic biochemical methods based on modern separation and mass spectrometry techniques. This led to subsequent development of metabolomic laboratory and relevant working pipelines.  He is involved in research of nucleotide metabolism in relation to inherited metabolic disorders, expanded newborn metabolic screening, developing novel statistical approaches to metabolic data and drug metabolism research in relation to cancer. In the last period he is focused on clinical applications and data analysis in metabolomics.

From a technological point of view is skilled in techniques such as liquid chromatography, capillary electrophoresis, mass spectrometry (QqQ, Orbitrap, ESI, high-throughput flow injection analysis, MS2/MS3 HR/AM fragmentation).

Last couple of years he has focused on metabolomics (targeted/untargeted approach - data processing, interpretation, analysis of bodyfluids, cells, tissues – clinical applications).

Journals

KANAGARATHAM, C., A. KALIVODOVÁ, L. NAJDEKR, D. FRIEDECKÝ, T. ADAM, M. HAJDÚCH, J. DE SANCTIS, D. RADZIOCH
Fenretinide prevents inflammation and airway hyperresponsiveness in a mouse model of allergic asthma. American Journal of Respiratory Cell and Molecular Biology. 2014, 51(6), 783-92, ISSN: 1535-4989, PMID: 24885263,
BACOVSKY, J., M. MYSLIVECEK, J. MINARIK, V. SCUDLA, T. PIKA, J. ZAPLETALOVÁ, P. PETROVA, M. BARTKOVA, T. ADAM, S. GRONOWITZ
Analysis of thymidine kinase serum levels by novel method DiviTum™ in multiple myeloma and monoclonal gammopathy of undetermined significance - comparison with imaging methods 99mTc-MIBI scintigraphy and 18F-FDG PET/CT. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2014, 159(1), 100-103, ISSN: 1213-8118, PMID: 24572488,
MIČOVÁ, K., D. FRIEDECKÝ, E. FABER, T. ADAM
Isotope dilution direct injection mass spectrometry method for determination of four tyrosine kinase inhibitors in human plasma. Talanta. 2012, 93(-), 307-317, ISSN: 0039-9140, PMID: 22483915,

Open positions

1 Medical biology
Project: Cellular fluxomic analysis for the research of pathobiochemical processes
Supervisors: Adam Tomáš Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 place in full-time or combined form of study
2 Molecular and Translational Medicine
Project: Cellular fluxomic analysis for research of pathobiochemical processes
Supervisors: Adam Tomáš Ph.D.
Available: 1
Intended for: Doctoral training
Project: Diagnosis and treatment of rare diseases
Supervisors: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D., Adam Tomáš Ph.D.
Available: 3
Intended for: Doctoral training
Summary: 3 full-time positions