The research is focused on human virology, public health surveillance, the molecular mechanisms of virus-driven infections, diseases and specifically carcinogenesis. The group is focused mainly on HPV-associated diseases, SARS-CoV-2 immunity, and cancer genetics. The Laboratory of virology and molecular carcinogenesis was recently established as a junior research group. The researchers from the Laboratory of virology and molecular carcinogenesis are involved in molecular investigation of human papillomaviruses (HPV) and recently in SARS-CoV-2 infections. The workplace is fully equipped with state-of-the-art instruments for genetic and molecular biology analyses of human biological materials.
Virology and molecular carcinogenesis
Laboratory of Experimental Medicine
Research interests
- Human virology
- Public health surveillance
- Molecular carcinogenesis of HPV-driven cancers
- SARS-CoV-2 immunity
- National screening and vaccination programmes improvement
- New approaches in screening testing
- Diagnostic and therapeutic targets
Current projects
- KOPRETINA trial – The main goal of the study is to determine the prevalence and genotype distribution of Human Papillomavirus in vaccinated/unvaccinated Czech women. The second goal is to evaluate the usage of self-sampling device mainly in women who do not participate in cytology-based cervical cancer screening and in women who participate in cervical cancer screening.
- Liquid biopsies - a possible tool for treatment monitoring and early recurrence detection in HPV-associated diseases – The main goal of the study is monitoring of HPV DNA dynamics in patients with HPV-positive oropharyngeal and cervical cancer/precancer. The second goal is to evaluate the importance of circulating HPV DNA in liquid biopsies for the treatment efficacy and relapse monitoring.
- PREVAL - Study of Collective Immunity – The main goal of the study is to evaluate the amount of SARS-CoV-2 antibodies, the presence of infection and the cell immunity response in people from Olomouc region.
Selected publications
Prevalence of Human Papillomavirus Infection in Oocyte Donors and Women Treated for Infertility: An Observational Laboratory-Based Study. European Journal of Obstetrics & Gynecology and Reproductive Biology: X. 2019, 4, 100068, ISSN: 2590-1613, PMID: 1517300,
Prevalence of Human Papillomavirus Infection in Oocyte Donors and Women Treated for Infertility: An Observational Laboratory-Based Study. European Journal of Obstetrics & Gynecology and Reproductive Biology: X. 2019, 4, 100068, ISSN: 2590-1613, PMID: 1517300,
Open positions
1 Molecular and Translational Medicine
| Project: | Genetic and epigenetic biomarkers in health and disease |
|---|---|
| Supervisors: | Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D. |
| Available: | 5 |
| Intended for: | Doctoral training |