Hajduová Katarína

Multimodal imaging methods for preclinical testing of novel bioactive molecules

New PSMA ligands for prostate cancer diagnosis and therapy

Nanoparticles for detection of sentinel lymph nodes

My diploma thesis  was focused on new radioactive labelled PSMA ligands for therapy and imaging of prostate cancer, where we used human prostate cancer xenografts in mice. We established  basic in vitro and in vivo charasterictics of these compounds such as Stability in human blood, hydrophophicity, rate of binding to human blood. We used modalities such as HPLC with radiodetector, PET-CT and for detection of radioactivity in organs we used gamma counter. As a part of my doctoral trainig my focus is on testing another compounds which can be used for radiolabelled multimodal imaging and therapy.