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Akademický titul: Professor
Telefon: +420 585 632 197
Skupiny: PŘÍRODOVĚDECKÁ FAKULTA, IMTM, MEDCHEM, PERSONÁL, VEDOUCÍ

O mně

I am a scientist in the field of medicinal chemistry with current focus on natural products with various biological activities. Since 2012 I am a leader of an independent research group that currently has 2 postdocs, 4 PhD and 8 undergraduate students. Our research consists of organic synthesis, evaluation of activities and mechanism of action. I have been a PI of several grant projects from Czech Science Agency and from the Ministry of Health of the Czech Republic. Currently I serve on an evaluation panel of Czech Science Agency (P207). Earlier in my career, I was also involved in nucleic acid research, enzymology and biochemistry in general. In addition, I teach classes on bioorganic chemistry, chemical biology, and chemistry of nucleic acids. Published more than 40 papers, 3 book chapters, 4 patents, >1500 SCI citations, H-index 21.

ORCID: http://orcid.org/0000-0002-8249-028X 

Researcher ID: C-9611-2010 

Journals

URBAN, M., V. ŠLACHTOVÁ, L. BRULÍKOVÁ
Small organic molecules targeting the energy metabolism of Mycobacterium tuberculosis. European Journal of Medicinal Chemistry. 2021, 212, 113139, ISSN: 0223-5234, PMID: 33422979,
CHASÁK, J., V. ŠLACHTOVÁ, M. URBAN, L. BRULÍKOVÁ
Squaric acid analogues in medicinal chemistry. European Journal of Medicinal Chemistry. 2021, 209, 112872, ISSN: 0223-5234, PMID: 33035923,
Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid. European Journal of Medicinal Chemistry. 2019, 185, 111806, ISSN: 0223-5234, PMID: 31677446,

Master mentorship

Šťastná Barbora

Synthesis of triterpenes suitable for their visualization in the cell

Stav: Absolvoval od 2023 do 2025.

Vojtušová Lucie

Development of new triterpenoid derivatives with cytotoxic activity

Stav: Probíhající od 2024.

Kúdelová Kristína

Synthesis of betulin derivatives with cytotoxic effect

Stav: Absolvoval od 2022 do 2024.

Bachelor mentorship

Vojtušová Lucie

Development of new triterpenoid derivatives with cytotoxic activity

Stav: Graduated od 2022 do 2024.

Maršálková Natálie

Preparation of new cytotoxic betulin ester derivatives

Stav: Ongoing od 2024 do 2025.

Kočvarová Markéta

Heterocyclic triterpenoids

Stav: Probíhající od 2024.

Volná místa

1 Molecular and Translational Medicine
Projekt: Research and development of agents for cancer, neurodegenerative and infectious diseases
Vedoucí: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
K dispozici: 5
Určeno pro: Doctoral training
1 Molekulární a translační medicína
Projekt: Natural compounds with anti tumor activity
Vedoucí: Urban Milan Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Souhrn: 2 místa na plný úvazek