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Academic title: Professor
Phone: +420 585 632 197
Groups: FACULTY OF SCIENCE, IMTM, MEDCHEM, STAFF, SUPERVISOR

About me

I am a scientist in the field of medicinal chemistry with current focus on natural products with various biological activities. Since 2012 I am a leader of an independent research group that currently has 2 postdocs, 4 PhD and 8 undergraduate students. Our research consists of organic synthesis, evaluation of activities and mechanism of action. I have been a PI of several grant projects from Czech Science Agency and from the Ministry of Health of the Czech Republic. Currently I serve on an evaluation panel of Czech Science Agency (P207). Earlier in my career, I was also involved in nucleic acid research, enzymology and biochemistry in general. In addition, I teach classes on bioorganic chemistry, chemical biology, and chemistry of nucleic acids. Published more than 40 papers, 3 book chapters, 4 patents, >1500 SCI citations, H-index 21.

ORCID: http://orcid.org/0000-0002-8249-028X 

Researcher ID: C-9611-2010 

Journals

Substituted dienes prepared from betulinic acid - Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters. European Journal of Medicinal Chemistry. 2021, 224, 113706, ISSN: 0223-5234, PMID: 34311159,
BACHOŘÍK, J., M. URBAN
Biocatalysis in the Chemistry of Lupane Triterpenoids. Molecules. 2021, 26(8), 2271, ISSN: 1420-3049, PMID: 33919839,  PDF.
GONZALES, G., J. HODOŇ, A. KAZAKOVA, C. D´ACUNTO, P. KANOVSKY, M. URBAN, M. STRNAD
Novel pentacyclic triterpenes exhibiting strong neuroprotective activity in SH-SY5Y cells in salsolinol- and glutamate-induced neurodegeneration models. European Journal of Medicinal Chemistry. 2021, 213, 113168, ISSN: 0223-5234, PMID: 33508480,

Master mentorship

Hodoň Jiří, Ph.D.

Cytotoxic active triterpenes and their mechanism of action

Status: Graduated from 2015 to 2017.

Tomeček Libor

Preparation of new complex platinum compounds using terpene ligands

Status: Graduated from 2023 to 2025.

Novák Jakub

Visualization of triterpenes in tumor cells

Status: Graduated from 2023 to 2025.

Bachelor mentorship

Kúdelová Kristína

Synthesis of new semisynthetic derivatives of betulin

Status: Graduated from 2021 to 2022.

Šťastná Barbora

Synthesis of triterpenes suitable for their visualization in the cell

Status: Graduated from 2021 to 2022.

Novák Jakub

Visualization of triterpenes in tumor cells

Status: Graduated from 2021 to 2023.

Open positions

2 Molecular and Translational Medicine
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training
Project: Natural compounds with anti tumor activity
Supervisors: Urban Milan Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 full-time positions