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Academic title: Professor
Phone: +420 585 632 197
Groups: FACULTY OF SCIENCE, IMTM, MEDCHEM, STAFF, SUPERVISOR

About me

I am a scientist in the field of medicinal chemistry with current focus on natural products with various biological activities. Since 2012 I am a leader of an independent research group that currently has 2 postdocs, 4 PhD and 8 undergraduate students. Our research consists of organic synthesis, evaluation of activities and mechanism of action. I have been a PI of several grant projects from Czech Science Agency and from the Ministry of Health of the Czech Republic. Currently I serve on an evaluation panel of Czech Science Agency (P207). Earlier in my career, I was also involved in nucleic acid research, enzymology and biochemistry in general. In addition, I teach classes on bioorganic chemistry, chemical biology, and chemistry of nucleic acids. Published more than 40 papers, 3 book chapters, 4 patents, >1500 SCI citations, H-index 21.

ORCID: http://orcid.org/0000-0002-8249-028X 

Researcher ID: C-9611-2010 

Journals

Novel C-2 Aromatic Heterocycle-Substituted Triterpenoids Inhibit Hedgehog Signaling in GLI1 Overexpression Cancer Cells. ACS Omega. 2025, 10(10), 10617-10632, ISSN: 2470-1343, PMID: 40124057,  PDF.
Triterpenoid phthalimides as selective anti-cancer agents targeting mitochondrial apoptosis. European Journal of Medicinal Chemistry. 2024, ISSN: 0223-5234, PMID: 39673861,  PDF.
PORUBSKÝ, M., J. HODOŇ, J. STANKOVÁ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN, J. HLAVÁČ
Near-infrared pH-switchable BODIPY photosensitizers for dual biotin/cRGD targeted photodynamic therapy. Journal of photochemistry and photobiology. 2024, 113010, ISSN: 1011-1344, PMID: 39141981,

Doctoral mentorship

Borková Lucie Ph.D.

Modification of triterpenes with the use of transition metal catalyzed reactions and nucleophilic substitution

Status: Graduated from 2014 to 2018.

Pokorný Jan Ph.D.

Modifications of double bonds in triterpenes with antitumor activity

Status: Graduated from 2015 to 2022.

Hodoň Jiří, Ph.D.

Cytotoxic active triterpenes and their mechanism of action

Status: Graduated from 2017 to 2024.

Master mentorship

Šidová Veronika

Synthesis of new cytotoxic triterpenoid derivatives using click chemistry

Status: Graduated from 2013 to 2015.

Zoufalý Pavel

Exploraton of click reaction approach in triterpenoids containing propargyl substituent

Status: Graduated from 2014 to 2016.

Šebrle Marek

Study on metathesis triterpenoids with exoskeletarnimi double bonds

Status: Graduated from 2011 to 2017.

Bachelor mentorship

Horka Vladimír

Conjugates of betulin prepared by cycloaddition reactions

Status: Graduated from 2016 to 2018.

Olejníková Denisa

Synthesis of new lupane derivatives modified at position 20 or 30

Status: Graduated from 2016 to 2018.

Orság Šimon

Preparation of new heterocyclic derivatives of triterpene

Status: Graduated from 2018 to 2020.

Open positions

2 Molecular and Translational Medicine
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training
Project: Natural compounds with anti tumor activity
Supervisors: Urban Milan Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 full-time positions