Jakubcová Nikola

Academic title: Mgr.

Phone: + 420 585 632 183

Groups: CHEMISTRY, IMTM, MEDCHEM, STAFF

In our research, we focus on the preparation of semi-synthetic derivatives of triterpenes with the aim of improving their biological properties. I am currently focusing on the preparation of heterocyclic derivatives of triterpenic acids with potential cytotoxic activity.

FRYDRYCH, I., B. CHROMA, L. SLAVIKOVA, J. POKORNÝ, N. JAKUBCOVÁ, S. LUDHA, S. GURSKÁ, J. ŘEHULKA, B. LIŠKOVÁ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN

Novel C-2 Aromatic Heterocycle-Substituted Triterpenoids Inhibit Hedgehog Signaling in GLI1 Overexpression Cancer Cells. ACS Omega. 2025, 10(10), 10617-10632, ISSN: 2470-1343, PMID: 40124057, PDF.

KAZAKOVA, A., I. FRYDRYCH, N. JAKUBCOVÁ, J. POKORNÝ, B. LIŠKOVÁ, S. GURSKÁ, R. BURIÁNOVÁ, A. PRIBYLKA, P. DŽUBÁK, M. HAJDÚCH, M. URBAN

Triterpenoid phthalimides as selective anti-cancer agents targeting mitochondrial apoptosis. European Journal of Medicinal Chemistry. 2024, ISSN: 0223-5234, PMID: 39673861, PDF.

KAZAKOVA, A., I. FRYDRYCH, N. JAKUBCOVÁ, J. POKORNÝ, B. LIŠKOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN

Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells - Synthesis, potency, and mitochondrial mechanism of action. European Journal of Medicinal Chemistry. 2024, 269, 116336, ISSN: 0223-5234, PMID: 38520761, PDF.

Jakubcová Nikola

About me

Journals