Urban Milan Ph.D.

Academic title: Professor

Phone: +420 585 632 197

Groups: FACULTY OF SCIENCE, IMTM, MEDCHEM, STAFF, SUPERVISOR

I am a scientist in the field of medicinal chemistry with current focus on natural products with various biological activities. Since 2012 I am a leader of an independent research group that currently has 2 postdocs, 4 PhD and 8 undergraduate students. Our research consists of organic synthesis, evaluation of activities and mechanism of action. I have been a PI of several grant projects from Czech Science Agency and from the Ministry of Health of the Czech Republic. Currently I serve on an evaluation panel of Czech Science Agency (P207). Earlier in my career, I was also involved in nucleic acid research, enzymology and biochemistry in general. In addition, I teach classes on bioorganic chemistry, chemical biology, and chemistry of nucleic acids. Published more than 40 papers, 3 book chapters, 4 patents, >1500 SCI citations, H-index 21.

ORCID: http://orcid.org/0000-0002-8249-028X

Researcher ID: C-9611-2010

KAZAKOVA, A., I. FRYDRYCH, N. JAKUBCOVÁ, J. POKORNÝ, B. LIŠKOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN

Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells - Synthesis, potency, and mitochondrial mechanism of action. European Journal of Medicinal Chemistry. 2024, 269, 116336, ISSN: 0223-5234, PMID: 38520761, PDF.

BORKOVÁ, L., I. FRYDRYCH, B. VRÁNOVÁ, N. JAKUBCOVÁ, B. LIŠKOVÁ, P. DŽUBÁK, P. PAVLIŠ, M. HAJDÚCH, M. URBAN

Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes. European Journal of Medicinal Chemistry. 2022, 244, 114850, ISSN: 0223-5234, PMID: 36283179,

HODOŇ, J., I. FRYDRYCH, Z. TRHLÍKOVÁ, J. POKORNÝ, L. BORKOVÁ, S. BENICKÁ, M. VLK, B. LIŠKOVÁ, A. KUBÍČKOVÁ, M. MEDVEDÍKOVÁ, M. PISÁR, J. ŠAREK, V. DAS, A. LIGASOVÁ, K. KOBERNA, P. DŽUBÁK, M. HAJDÚCH, M. URBAN

Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs. European Journal of Medicinal Chemistry. 2022, 243, 114777, ISSN: 0223-5234, PMID: 36174412, PDF.

Borková Lucie Ph.D.

Modification of the position 2 in betulin, allobetulin and betulinic acid with polar substituents

Status: Graduated from 2012 to 2014.

2 Molecular and Translational Medicine

Project:	Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors:	De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available:	5
Intended for:	Doctoral training

Project:	Natural compounds with anti tumor activity
Supervisors:	Urban Milan Ph.D.
Available:	2
Intended for:	Doctoral training
Summary:	2 full-time positions

Urban Milan Ph.D.

About me

Journals

Doctoral mentorship

Šťastná Barbora

Master mentorship

Orság Šimon

Jurčeka Ondřej

Borková Lucie Ph.D.

Bachelor mentorship

Trhlíková Zdeňka

Jurčeka Ondřej

Hodoň Jiří, Ph.D.

Open positions