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Academic title: Professor
Phone: +420 585 632 197
Groups: FACULTY OF SCIENCE, IMTM, MEDCHEM, STAFF, SUPERVISOR

About me

I am a scientist in the field of medicinal chemistry with current focus on natural products with various biological activities. Since 2012 I am a leader of an independent research group that currently has 2 postdocs, 4 PhD and 8 undergraduate students. Our research consists of organic synthesis, evaluation of activities and mechanism of action. I have been a PI of several grant projects from Czech Science Agency and from the Ministry of Health of the Czech Republic. Currently I serve on an evaluation panel of Czech Science Agency (P207). Earlier in my career, I was also involved in nucleic acid research, enzymology and biochemistry in general. In addition, I teach classes on bioorganic chemistry, chemical biology, and chemistry of nucleic acids. Published more than 40 papers, 3 book chapters, 4 patents, >1500 SCI citations, H-index 21.

ORCID: http://orcid.org/0000-0002-8249-028X 

Researcher ID: C-9611-2010 

Journals

URBAN, M., V. ŠLACHTOVÁ, L. BRULÍKOVÁ
Small organic molecules targeting the energy metabolism of Mycobacterium tuberculosis. European Journal of Medicinal Chemistry. 2021, 212, 113139, ISSN: 0223-5234, PMID: 33422979,
CHASÁK, J., V. ŠLACHTOVÁ, M. URBAN, L. BRULÍKOVÁ
Squaric acid analogues in medicinal chemistry. European Journal of Medicinal Chemistry. 2021, 209, 112872, ISSN: 0223-5234, PMID: 33035923,
Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid. European Journal of Medicinal Chemistry. 2019, 185, 111806, ISSN: 0223-5234, PMID: 31677446,

Master mentorship

Šťastná Barbora

Synthesis of triterpenes suitable for their visualization in the cell

Status: Graduated from 2023 to 2025.

Vojtušová Lucie

Development of new triterpenoid derivatives with cytotoxic activity

Status: Ongoing from 2024.

Kúdelová Kristína

Synthesis of betulin derivatives with cytotoxic effect

Status: Graduated from 2022 to 2024.

Bachelor mentorship

Vojtušová Lucie

Development of new triterpenoid derivatives with cytotoxic activity

Status: Graduated from 2022 to 2024.

Maršálková Natálie

Preparation of new cytotoxic betulin ester derivatives

Status: Ongoing from 2024 to 2025.

Kočvarová Markéta

Heterocyclic triterpenoids

Status: Ongoing from 2024.

Open positions

2 Molecular and Translational Medicine
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training
Project: Natural compounds with anti tumor activity
Supervisors: Urban Milan Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 full-time positions