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Phone: +420 585 632 234
Groups: IMTM, LIG, STAFF, SUPERVISOR

About me

Head of the DNA Replication Dynamics research group at the Institute of Molecular and Translational Medicine.

Researcher with extensive expertise in DNA replication and the DNA damage response.

Author of 18 scientific publications, with more than 2300 citations and an h-index of 16.

Evaluator for national and international grant competitions and research assessment.

Reviewer for international peer-reviewed scientific journals.

Supervisor and mentor of Bachelor’s, Master’s, and PhD students.

 

Positions are available for motivated Master’s and PhD students interested in DNA replication and clinically relevant research aimed at improving PARP inhibitor therapy. Please contact me for further information.

Journals

The need for speed: drivers and consequences of accelerated replication forks. Communications Biology. 2025, 8(1), 1538, ISSN: 2399-3642, PMID: 41198817,  PDF.
DNA polymerase α-primase facilitates PARP inhibitor-induced fork acceleration and protects BRCA1-deficient cells against ssDNA gaps. Nature Communications. 2024, 15(1), 7375, ISSN: 2041-1723, PMID: 39191785,  PDF.
Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments. Life Science Alliance. 2022, 5(12), e202201560, ISSN: 2575-1077, PMID: 36260751,

Doctoral mentorship

Machačová Zuzana M.Sc.

Molecular mechanisms regulating DNA replication

Status: Graduated from 2021 to 2025.

Turi Zsofia M.Sc.

Replication stress induced cellular senescence in primary fibroblast cell lines

Status: Graduated from 2014 to 2019.

Lukáč Dávid MSc

DNA replication and cancer

Status: Graduated from 2020 to 2025.

Master mentorship

Haroková Barbora

Ribosomal stress and activation of p53

Status: Graduated from 2016 to 2018.

Vévodová Karolína

DNA replication and cancer

Status: Graduated from 2024 to 2026.

Najdekova Alica

Regulation of replication fork rate

Status: Ongoing from 2025.

Bachelor mentorship

Šanovec Ondřej

Cellular response to ribosomal stress

Status: Graduated from 2017 to 2019.

Baťová Adéla

Cellular response to genotoxic and replication stress

Status: Graduated from 2019 to 2021.

Bartošová Renata

DNA replication and cancer

Status: Graduated from 2019 to 2021.

Open positions

2 Molecular and Translational Medicine
Project: Cellular stress in health and disease
Supervisors: Mistrík Martin Ph.D., Moudrý Pavel Ph.D., Škrott Zdeněk Ph.D.
Available: 3
Intended for: Doctoral training
Project: DNA replication in human pathophysiology
Supervisors: Moudrý Pavel Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 full-time position